A bone clamp

How a DNA polymerase clamp loader opens a sliding clamp.

Processive chromosomal replication relies on sliding DNA clamps, which are loaded onto DNA by pentameric clamp loader complexes belonging to the AAA+ family of adenosine triphosphatases (ATPases). We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The clamp loader traps a spiral conformation of the ope...

A New Eyelid Clamp

A new bronchus clamp.

Bronchus clamps for use in lung resection have never been entirely satisfactory. The very large number of models available make this plain. When lung resection presents no problems almost any model of bronchus clamp is suitable. In a technically difficult situation all have shortcomings. The basic requirements of a bronchus clamp are: 1. It must be easy to pass with the minimum of dissection of...

A new stomach clamp.

An efficient stomach clamp is one which exerts an even and sufficient pressure across the whole width of the stomach without causing undue trauma at any one point. Very few stomach clamps at present obtainable fulfil these conditions satisfactorily because they ate mainly constructed on the ' bow handle ' principle, or are of the crushing type. All clamps of this type necessarily exert most pre...

StdpC: a modern dynamic clamp.

With the advancement of computer technology many novel uses of dynamic clamp have become possible. We have added new features to our dynamic clamp software StdpC ("Spike timing-dependent plasticity Clamp") allowing such new applications while conserving the ease of use and installation of the popular earlier Dynclamp 2/4 package. Here, we introduce the new features of a waveform generator, free...